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Episode #84: Convicted vs. Disciplined Healthcare VCs, The Capitalist Multiverse, The Untrainable

This week we dig into a piece from Halle Tecco exploring how healthcare VCs are splitting into two camps on ownership discipline as AI drives valuations to decade highs. We also break down Sam Lessin’s argument that the SpaceX IPO signals the end of the DCF as the only globally scalable story of value, and what it means that minority belief systems can now pool conviction at trillion-dollar scale. We close with Sarah Guo’s “The Untrainable,” a sharp framework for understanding where real moats exist in the AI era and why the defensible work is exactly the stuff that can’t be benchmarked. Tune in for a packed episode touching on venture math, narrative-driven markets, and what it actually takes to build something durable when the models keep getting smarter.

Convicted or Disciplined: How Healthcare VCs Are Split on Investing - Halle Tecco

Massively Better Healthcare
Convicted or disciplined: How healthcare VCs are split on investing
This piece concludes a two-part independent study I oversaw with Kyra Gardner and Andy Wang (both CBS ‘26…
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The Real SpaceX IPO Lesson: We Live in a Capitalist Multiverse of Value - Sam Lessin

The Untrainable - Sarah Guo

Sarah Guo
The Untrainable
The mid-2026 investor’s version of AI psychosis is a despair that nothing is investable, that we should put all our money into Anthropic and Nvidia and go home. I have never felt it. I have been sure the models are smarter than me for several sub-versions now, I’d be a happy buyer of Anthropic and Nvidia at the market price, and all my smartest friends …
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